Eurofins Central Laboratory

Online Literature Library

Endocrinology

Obesity

The role of secreted factors in white and brown adipogenesis

CRISPR/Cas9 Inducible Gene Knockout in Brown Adipose Tissue

 

GPCR signaling pathway

Molecular pharmacological analysis of the human MrgD receptor New insights into signaling

Eurofins Services Offered:  MRGPRD CHO-K1 β-arrestin GPCR assay

 

Diabetes

CPL207280, a Novel G Protein–Coupled Receptor 40/Free Fatty Acid Receptor 1–Specific Agonist, Shows a Favorable Safety Profile and Exerts Antidiabetic Effects in Type 2 Diabetic Animals

Ophthalmology

Trachoma

Comparison of genovars and Chlamydia trachomatis infection loads in ocular samples from children in two distinct cohorts in Sudan and Morocco

Eurofins Services Offered:  Sanger Sequencing of purified PCR specimens

 

Leber congenital amaurosis (LCA)

Allele-specific gene editing to rescue dominantCRX-associated LCA7phenotypes in a retinal organoid model

Pharmacology/Toxicology

Tobacco/Nicotine

Use of a rapid human primary cell-based disease screening model, to compare next generation products to combustible cigarettes

Eurofins Services Offered:  Authorship, Biologically Multiplexed Activity Profiling

 

Chemical Language Models

Leveraging molecular structure and bioactivity with chemical language models for drug design

Gene Therapy

Plasmid DNA Purification

Recombinant expression of Barnase in Escherichia coli and its application in plasmid purification

Eurofins Service Offering:  Construction of plasmid PF1680

Trauma

Rabdomyolysis

Compromised mitochondrial quality control triggerslipin1-related rhabdomyolysis

Eurofins Services Offered:  Oligonucleotides, Reagents

Neurology

 Blood Brain Barrier

 Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening

Vaccines

Gonorrhea

Preclinical Testing of Vaccines and Therapeutics for Gonorrhea in Female Mouse Models of Lower and Upper Reproductive Tract Infection

Eurofins Services Offered:  estradiol-treated, ovariectomized (Ov-) BALB/c In Life species

 

Cytomegalovirus (CMV)

The impact of a human cytomegalovirus subviral particle vaccine on the host cell proteome and on virus replication

Eurofins Service Offerings:  Oligonucleotides for qPCR

 

SAR-CoV-2

High level of protection against COVID-19 after two doses of BNT162b2 vaccine in the working age population–first results from a cohort study in Southern Sweden

Hepatology

NASH

An Engineered Fatty Acid, Icosabutate, Targets Free-Fatty Acid Receptor 4 (GPR120) via the β-arrestin-2 Internalisation Pathway

Infections and Infectious Disease

Covid-19

High Prevalence of Pre-Existing Liver Abnormalities Identified Via Autopsies in COVID-19: Identification of a New Silent Risk Factor?

Eurofins Services Offered:  PCR based testing for SARS-CoV-2

Oncology

Colorectal Cancer

TMEM180 contributes to SW480 human colorectal cancer cell proliferation through intra-cellular metabolic pathways

Eurofins Service Offering:  RNA quality checking, library preparation, and sequencing on the HiSeq 4000 platform (Illumina)

 

A human ex vivo coculture model to investigate peritoneal metastasis and innovative treatment options

Eurofins Service Offering:  Cell line Authentication by STR analysis.

 

Breast Cancer

Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

Eurofins Services Offered:  Sanger Sequencing

 

Triple-Action Platinum(IV) Prodrugs

Structure−Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands

Eurofins Services Offered:  Primer Sequences

 

T Cell Immunotherapy

Next-generation TCR-transgenic T cells for Immunotherapy

Eurofins Services Offered:  Sanger sequencing

 

Monovalent Protein Therapeutics

In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance

Eurofins Services Offered:  Oligonucleotides

 

Endometrial Cancer

Pre-treatment risk assessment of women with endometrial cancer: differences in outcomes of molecular and clinical classifications in the Slovenian patient cohort

Eurofins Services Offered:  Sanger Sequencing

 

Ewing Sarcoma

Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer

Eurofins Services Offered:  Oligonucleotides

 

Glioblastoma

Modeling glioblastoma heterogeneity as a dynamic network of cell states

Eurofins Services Offered:  STR Profiling

 

Melanoma

Genetic Variants and Somatic Alterations Associated with MITF-E318K Germline Mutation in Melanoma Patients

IER2-induced senescence drives melanoma invasion through osteopontin

Gastroenterology

ulcerative colitis

Prebiotic Galactooligosaccharide Supplementation in Adults with Ulcerative Colitis: Exploring the Impact on Peripheral Blood Gene Expression, Gut Microbiota, and Clinical Symptoms

Cardiology/Vascular Disease

Essentially Fatty Acids

Essential Fatty Acids as Biomedicines in Cardiac Health

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